Homology-Directed Repair: How the Cell Edits DNA After a CRISPR-Induced Break

Sometimes DNA breaks because of insults like x-rays, UV rays, or genetic scissors (e.g., CRISPR-Cas9). DNA breakage can have serious consequences if not corrected. Luckily, the cell has mechanisms to repair those breaks, including one known as homology-directed repair. In this fun animated clip, scientists describe how homology-directed repair works in an accessible way. You’re left with a haiku to better remember it. This clip was taken from Human Nature, the documentary which explores the discovery and future implications of the CRISPR-Cas9 genome editing technology. #HDR #HomologyDirectedRepair #CRISPR #DNARepair #RepairMechanism #DNABreaks #DoubleStrandBreaks #CRISPRCas9Mechanism #FyodorUrnov #GeneEditing #HumanNatureDocumentary Related Resources: Human Nature, the documentary: CRISPR 101: Homology Directed Repair (Addgene): Credits: This clip was taken from the feature-length