trypanosoma cruzi development and life cycle in vector || Chagas disease

Development and life cycle of Trypanosoma cruzi in insect vector reduviid bugs. Trypanosoma cruzi is a parasite belonging to Hemoflagellates group. Development of Trypanosoma cruzi ininvertebrate host, that is Reduviid bugs starts with ingestion of broader less motile trypomastigote forms that are present in blood of infected vertebrate human host, are transmitted to reduviid bugs during the blood meal. Trypomastigote forms transform into amastigote forms in the foregut, that is stomach. Further amastigote transforms into epimastigote and spheromastigote forms. Some intermediate form of parasites is destroyed in foregut. Epimastigotes passes in gut further to the midgut or intestine. Epimastigotes forms multiply by binary fission and attaches to the gut epithelial lining. This attachment to the epithelial cells is due to presence of flagellum of epimastigote form. Further the epimastigote form travel to the hindgut, that is rectum. They finally transform into metacyclictrypomastigote forms in the hindgut