ABO Blood group problem and solution

ABO BLOOD GROUP SYSTEM ANTIGENS AND ANTIBODIES Definition: Blood group system A series of antigens exhibiting similar serological and physiological characteristics, and inherited according to a specific pattern. Importance of the ABO system: Most important (clinically significant) Blood Group System for transfusion practice Why? This is the only blood group system in which antibodies are consistently, predictably, and naturally present in the serum of people who lack the antigen. Therefore ABO compatibility between donor and recipient is crucial since these strong, naturally occurring A and B antibodies are IgM and can readily activate complement and cause agglutination. If ABO antibodies react with antigens in vivo, result is acute hemolysis and possibly death. Indications for ABO grouping: ABO grouping is required for all of the following individuals: Blood Donors-since it can be life threatening to give the wrong ABO group to the patient. Transfusion recipients-since we need to know the donor blood is ABO compatible. Transplant Candidates and Donors-ABO antigens are found in other tissues as well. Therefore the transplant candidates and donors must be compatible. Prenatal Patients-To determine whether the mothers may have babies who are suffering from ABO-HDN. It is also beneficial to know the ABO group should she start hemorrhaging. Newborns (sometimes) If the baby is demonstrating symptoms of Hemolytic Disease of the Newborn, the ABO group needs to be determined along with Rh and others. Paternity testing Since the inheritance of the ABO Blood Group System is very specific, this serves as one of the first methods to determine the likelihood that the accused father is the father or not. #genome #alleles #gene #IgM #chromosome #Genetics #Allele #protein #genotype #DNA #RNA #genes #bloodGroupSystem #Rh #ABOGroup #genomics #Genetics101 #Eukaryotes #GeneStructure #ABOAntibodies #Prokaryotes #Eukaryotic #Chromosomes #geneExpression #genomes #Proteins #hemolysis #GeneticTesting #locus #MolecularBiology #GeneticExamQuestionsSolutions #geneticCode #aboBloodGroup #GeneticsLecture #GeneticsExamQuestionsSolutions #DNAMolecule #antigens #rRNA #phenotype #Cancer