Peculiar properties of mitochondrial disease pedigree

Conditions caused by a mutation in the mitochondrial DNA have unusual patterns. Both males and females are affected the condition is transmitted through the female to her offspring if a male has the trait and his spouse doesn’t, their offspring won’t have the trait In the first pedigree, you will see that when a female has the trait, all of her offspring have the trait, but in the second pedigree, this is not necessarily the case. The expression of mitochondrial conditions is variable. Inside each cell, there are several mitochondria. The number of mitochondria that carry the mutation can vary. A certain proportion of mutant mitochondria within a cell can be tolerated and the disease will not be expressed in the organism. A larger proportion of mutant mitochondria however, may cause the disease to be expressed in the organism. You may want to use the first pedigree to show your students how it is transmitted through the female, in the cytoplasm of her egg cell. If your students study mitochondria, their genetic makeup and how they reproduce, you may want to use the second pedigree to show how the expression can vary depending on the proportion of mitochondria carrying the mutation. #genomics #viruses #Iherb #dominant #GeneticExamQuestionsSolutions #GeneticsExamQuestionsSolutions #centromeres #genes #Cancer #genome #gene #geneExpression #genotype #Diploid #BloodType #dnaMolecule #pedigreeAnalysisProbability #pedigreeAnalysisAnswers #pedigree #pedigreeCharts #genetics #HowToSolvePedigreeProblems #solvePedigreeProblems #solvingPedigreeProblems #pedigreeProblemsAndSolutions #howToAnalyzePedigree #analyzingPedigree #geneticsProblems