Time lapse video of the Chlamydia trachomatis developmental cycle.

Time lapse interference contrast microscopy of a cluster of McCoy cells cells in which a chlamydial inclusion develops (circled). An inclusion (arrowed) becomes visible by 12 hrs post infection. Cell lysis and release of C. trachomatis bacteria occurs at around the 78 hr mark. From the paper: Skilton RJ, Cutcliffe LT, Barlow D, Wang Y, Salim O, et al. (2009) Penicillin Induced Persistence in Chlamydia trachomatis: High Quality Time Lapse Video Analysis of the Developmental Cycle. PLoS ONE 4(11): e7723. d