11-Step and Scalable Total Synthesis of Hamigeran M Enabled by Five C−H Functionalizations
An organic chemistry minilecture on the Total Synthesis of Hamigeran M by Baiyang Jiang and Mingji Dai*. Highlights include multiple directed C-H activation reactions, a stereoselective hydrogen atom transfer reaction and Suzuki and Negishi cross-coupling reactions.
SUPPORT THE CHANNEL ON PATREON:
Socials:
References:
J. Am. Chem. Soc. 2021, 143, 48, 20084–20089 (This work)
J. Org. Chem. 2015, 80, 1, 304–312 (isolation)
Tetrahedron: Asymmetry. 2011, 22, 69-100 (Ketoester synthesis)
J. Am. Chem. Soc. 2017, 139, 23, 7864–7871 (Cresol Borylation)
J. Am. Chem. Soc. 2016, 138, 14, 4962–4971 (Hydrogen Atom Transfer)
J. Am. Chem. Soc. 2014, 136, 4, 1300–1303 (Hydrogen Atom Transfer)
Chem. Rev. 2016, 116, 15, 8912–9000 (Hydrogen Atom Transfer Review)
Org. Lett. 2009, 11, 8, 1837–1840 (TMPZnCl·LiCl Reagent)
Chem. Sci., 2013,4, 916-920 (Me4tBuPhos Pd G3 Catalyst)
J. Am. Chem. Soc. 2011, 133, 48, 19310–19313 (Rh Borylation)
1 view
1040
300
4 months ago 00:09:23 1
How to Find a Dropshipping Suppliers Today: Unveiling the Ultimate Guide😎
4 months ago 00:25:46 1
Kim Wilde - Top Of The Pops - All Appearances 1981-2006 [HD 50 FPS]
4 months ago 00:48:09 1
CAN TRUMP STOP WORLD WAR III?
4 months ago 00:58:07 1
MARION ChillStep | ChillOut Mix 2024 [1 Hour]
4 months ago 00:49:11 1
Andromida - Timeless (FULL ALBUM STREAM) // DJENT / PROGRESSIVE METAL