Antibodies in VR: Designing a Potential Vaccine against Alzheimer’s Disease

In this video, we explore the structures of amyloid-beta (Aβ) protein, specifically the N-truncated species which are implicated in the formation of soluble aggregates and plaques. These plaques are a defining characteristic of Alzheimer’s disease (AD). Based on structural analysis and structure based design, researchers have discovered a unique conformation and epitope in the N-terminal region of Aβ, which opens up new possibilities for both active and passive immunization strategies against AD. The ’TAPAS’ vaccine is an innovative approach that involves creating a stabilized cyclic form of Aβ1-14, drawing inspiration from its interaction with the murine derived antibody TAP01. Promising results from experiments involving the TAPAS vaccine in mouse models of AD show notable reductions in neuronal loss, improved brain glucose metabolism, and enhancements in memory function. These findings hold great potential for advancing Alzheimer’s research and potential treatments. Reference: Discovery of a novel pseudo β-hairpin structure of N-truncated amyloid-β for use as a vaccine against Alzheimer’s disease, P. Bakrania, et al., Molecular Psychiatry 2022 Vol. 27, Issue 2 Pages 840-848, DOI: Nanome is the ultimate interface for scientific discovery, starting with molecular data. Top R&D labs conduct cutting-edge research and make billion-dollar decisions in Nanome. But, Nanome isn’t just for experts, it’s also used by students and amateur scientists studying chemistry and biology. Anyone can build 3D molecules or simulate an entire protein made of hundreds of atoms, all in one collaborative environment. Transform the way you learn, design, and communicate molecular structures with Nanome. Available on the new Meta Quest Pro. Visit to download Nanome Get started today by downloading Nanome for free on: 1Oculus Rift/Rift S/Quest Link: SteamVR: Viveport App Lab: SideQuest: To learn more visit: or, follow us on: Twitter & Insta: @nanome_inc Be sure to also check out our blockchain platform, Matryx, which will serve as the backend IP tracking mechanism for Nanome. More info at