“What is Apoptosis?“ The Apoptotic Pathways and the Caspase Cascade

This 3D medical animation explains the functioning of the extrinsic and intrinsic apoptotic pathways. We start off by taking a look at the important role apoptosis plays in growth and development as well as removing DNA damaged cells. Then we see how activation of the caspase cascade occurs in each external and internal signalling pathway. Lastly we get a glimpse of cancer cells and their ability to block apoptosis. © Elvire Thouvenot-Nitzan, 2016 This resource is shared under Attribution-NonCommercial-NoDerivatives Creative Commons license (CC-BY-NC-ND 4.0). You are free to copy and reuse this for non-commercial purposes but we ask that you acknowledge “Elvire Thouvenot-Nitzan, created in collaboration with University of Dundee” when doing so. If you remix or modify this material, you may not distribute the modified material. Medical Animator Elvire Thouvenot-Nitzan BSc, MSc Centre for Anatomy and Human Identification, University of Dundee Medical Advisor and Pathology Instructor Richard Oparka MBChB, FRCPath Department of Histopathology, University of Dundee School of Medicine MSc Medical Art Advisor Caroline Erolin BA(Hons), PGCert, MPhil Centre for Anatomy and Human Identification, University of Dundee Technical Advisor Annie Campbell BSc, MSc Technology & Innovation Learning Team, University of Dundee School of Medicine Attributions: This animation features the track “Enrichment” by Podington Bear. The track is licensed under CC BY-NC 3.0 and has been edited to fit the animated short. The animation features sound effects from .